histone H3K36 trimethyltransferase activity [GO_0140955]

Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.
Tags:

histone H3K36 trimethyltransferase activity

ID: GO_0140955

Class

Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

Alternative Names

Synonym Scope Reference
histone H3K36 trimethylation broad synonym
histone H3-K36 trimethylation broad synonym
histone H3K36 mono/di/trimethylase activity exact synonym
histone H3K36 trimethylase activity exact synonym
histone lysine N-trimethyltransferase activity (H3-K36 specific) exact synonym